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The present experimental study was undertaken to observe the chronological changes of the pathological findings of the liver when fifty adult worms of Clonorchis sinensis were inoculated to each rat intraperitoneally. The pathological changes of the liver were investigated by conventional microscopy in the 5 groups, each group consisted of 5 rats, classified by the duration of observation period, i. e., 4, 10, 28, 56 and 180 days. The results obtained were summarized as follows. 1. Histopatologically the liver failed to show any parasitic worm inside the intrahepatic biliary system. However, multiple well formed egg-containing granulomas were present along the liver capsule. The worms recovered on the surface of the liver capsule were degenerated and necrotized. 2. Portal widening and focal phlebitis together with vascular dilatation were most common features seen in the liver. Occasionally, focal necrosis was also observed. 3. The bile duct in the liver showed mild dilatation of the lumen, epithelial of lining epithelium and periductal small round cell infiltration. Neither adenomatous hyperplasia nor portal fibrosis was seen in the whole experimental group.
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